You may use your "cheat sheets" but you should be able to answer the following questions without referring to any other resources.
Question 1 - Single Best Answer
Nucleocapsid structures for viruses include which of the following classifications?
A) linear and circular
B) single- and double-stranded
C) enveloped and naked
D) helical and icosahedral
E) protein or phospholipids
Question 2 - Single Best Answer
Which of the following viruses would be most stable in the environment?
A) Herpes
B) Smallpox
C) Influenza
D) Hepatitis A
Question 3 - Single Best Answer
The feature of influenza virus that allows it to undergo antigenic drift is
A) a high rate of mutation
B) the fact that the genome is + sense RNA
C) the fact that the genome is segmented
D) the G-C content of the neuraminidase gene
E) the exposed structure of the matrix protein
Question 4 - Single Best Answer
If deproteinized viral nucleic acid was added to cells, which would be able to make virus?
A) parainfluenza
B) rabies
C) polio
D) measles
E) poxvirus
Question 5 - Single Best Answer
Poliovirus proteins are synthesized
A) from individual segments of the genome; each segment codes for one protein
B) as a polyprotein that is posttranslationally cleaved
C) only after virus RNA is synthesized
D) only after the viral nucleic acid is integrated
Question 6 - Single Best Answer
Rotavirus vaccines
A) effectively prevent the respiratory disease
B) target the production of cell mediated immunity
C) were withdrawn from the market due to intussusceptions in vaccinees
D) target adults who most frequently suffer from rotavirus disease
E) were diarrheagenic so were withdrawn from the market
Question 7 - Single Best Answer
Rubella
A) is spread by an insect vector
B) causes a severe disease in children
C) is dangerous because it can have teratogenic effects( effects on a developing fetus)
D) is prevented by a killed viral vaccine; the killed vaccine is used because a live virus vaccine was found to harm unborn children
Question 8 - Single Best Answer
Individuals recovering from a recent bout of influenza are susceptible to bacterial pneumonia because
A) their ciliated respiratory epithelium has been de-nuded
B) their cell-mediated immunity has been compromised
C) complement has been inactivated
D) their lungs have filled with fluid
E) their B-cells have been infected
Question 9 - Single Best Answer
The reservoir for Eastern Equine Encephalitis is
A) mosquitos
B) ticks
C) birds
D) horses
E) humans
Question 10 - Single Best Answer
A dead-end host for Eastern Equine Encephalitis is
A) mosquito
B) tick
C) bird
D) horse
Question 11 - Single Best Answer
All types of papilloma have an equal chance of causing cervical carcinoma.
A) true
B) false
Question 12 - Single Best Answer
Which of the following viruses would you predict would contain enzymes as an obligatory part of their viral structure?
A) adenovirus
B) poliovirus
C) rabies virus
D) poliovirus and rabies
E) adenovirus and poliovirus
Question 13 - Single Best Answer
You add 1000 polystyrene balls to a 1 ml sample of virus and count an aliquot in the electron microscope. You see 15 polystyrene balls and 15 viruses. This means
A) there are 150 viruses/ml
B) there are 1500 viruses/ml
C) there are 100 viruses/ml
D) there are 1000 viruses/ml
E) you don't have enough information to tell
Question 14 - Single Best Answer
The first step in making new proteins for negative strand RNA viruses is
A) making double stranded RNA
B) making double stranded DNA
C) binding to the ribosomes
D) making messenger RNA
E) making + strand DNA
Question 15 - Single Best Answer
The sputum in primary influenza pneumonia is
A) rust colored
B) frothy and tinged with blood
C) like current jelly
D) bloody
Question 16 - Single Best Answer
Mr. Coffer had typical signs of flu (fever, muscle aches, cough) but after a week was beginning to feel better when he experienced a return of symptoms, a worsening of cough, and production of purulent sputum. He now almost certainly has
A) a genetic mutation of the flu virus
B) influenza viral pneumonia
C) bacterial pneumonia
D) Legionairre's disease
Question 17 - Single Best Answer
Prions can replicate because
A) they contain DNA
B) they contain RNA
C) they are transported from the intestine by retrograde axonal transport
D) they can change the tertiary structure of some proteins
Question 18 - Best 2 Answers
The tissue tropisms of most viruses are controlled by
A) their vectors
B) their nucleic acid
C) their replication proteins
D) their envelope proteins
E) it is DNA polymerase making mistakes that causes mutations
F) they replicate in the cytoplasm where the concentration of free radicals is higher
G) the U in RNA that replaces the T in DNA has more sites that can be mutated
H) the RNA polymerase does not have a proof-reading function
Question 19 - Single Best Answer
Amantadine is used to
A) shorten the duration of influenza rhinotracheatis
B) cure influenza pneumoniae
C) prevent bacterial pneumonia after influenza
D) as a mist for vaccination against influenza
Question 20 - Single Best Answer
In DNA viruses there is a correlation between size and
A) transmission ( small size means easier transmission)
B) ability to infect the GI tract ( small size means it is easier to get through the stomach and infect the intestine)
C) oncogenicity (large size means more oncogenic potential)
D) cell dependency (small size means more host functions are needed)
E) pathogenicity (large size viruses are more pathogenic)
Question 21 - Single Best Answer
Viruses used as vectors for gene therapy are
A) very large so they can carry lots of genes
B) non-enveloped so they will be more stable in the body
C) + strand RNA viruses so they can deliver messages to cells
D) all belong to the same family
E) none of the above
Question 22 - Single Best Answer
A plaque is
A) a focus of viral infection containing a homogeneous population of viruses.
B) a locus of hemaglutinnation
C) a manifestation of the most efficient way to measure virus particles
D) virus neutralized by antibody
E) a diploid cell line
Question 23 - Single Best Answer
A prokaryote is
A) a fibroblast
B) a cell without a nucleus
C) a virus without an envelope
D) a cell without a membrane
Question 24 - Single Best Answer
Mrs Jones has an IVSD (interventricular septal defect). She comes to your office because she has had a little "cold" for a day or so but then got profoundly tired suddenly this afternoon. You should
A) give her amantadine and send her home
B) tell her to call you in 3 days if she is not better
C) give her a flu shot
D) give her antibiotics to prevent bacterial pneumonia
E) admit her to the hospital to give her amantadine and supportive care
Question 25 - Single Best Answer
It is not a good idea to expose pregnant women to children with a rash. The virus(es) that are worrisome in such a case are
A) measles
B) measles and B19
C) rubella
D) rubella and measles
E) rubella and B19
Question 26 - Single Best Answer
A sure sign of measles is
A) conjunctivitis with a rash
B) white spots in the mouth
C) a runny nose with a rash
D) a cough
E) there is no pathognomonic sign of measles
Question 27 - Single Best Answer
Which of the following symptoms are UNIQUE to rabies?
A) low glucose in the CSF
B) headache and thirst
C) lack of muscle coordination
D) hydrophobia
E) anxiety
Question 28 - Single Best Answer
Stridor (a high pitched musical sound during inspiration) is a symptom of
A) mumps
B) influenza
C) bacterial pneumonia
D) croup
E) a Bach concerto
Question 29 - Single Best Answer
Cattle and horses are susceptible to rabies
A) True
B) False
Question 30 - Single Best Answer
BK and JC viruses are problems in
A) children
B) smokers
C) immunosuppressed patients
D) pregnant women
Question 31 - Single Best Answer
SSPE usually develops
A) 2 weeks after measles
B) 6 months after measles
C) 5 years after measles
D) 6 months after rabies
E) 5 years after EEEV
Question 32 - Single Best Answer
Carcinoma induced by papilloma virus is
A) (1) due to unregulated expression of HPV E6 and E7
B) (2) due to integration of viral DNA
C) (3) due to disruption of the E2 regulatory function
D) (4) due to unregulated cell cycling
E) all of the above
Question 33 - Single Best Answer
The most important aspect of the treatment of rotaviral diarrhea is
A) use the correct antiviral agent
B) confirm that it is bacterial before prescribing antibiotics
C) preventing dehydration
D) giving blood if too much is lost
Question 34 - Single Best Answer
Rotavirus diarrhea
A) is most common in adults
B) is most common in the winter months in temperate regions
C) occurs because of infection of the large colon
D) frequently causes cruise ships to return to port
E) is most common in AIDS patients