And, in our pre-diabetic patients, perhaps the thiazide might make them overtly diabetic, so we add Glyburide or something to that effect. And woops, we've added a little bit too much KCl back, now we have to drop that by prescribing something like Kayexalate.

And, before you know it, here's a patient not taking one drug, they're taking three or four medications, and I think a better strategy perhaps would be going back to the beginning and looking at what the root cause of some of these problems is in an effort to avoid having to tack one drug on top of the other, almost in a way like a dog who ends up chasing his tail. Well you know, where does the problem ultimately end up?

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