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Emergency Response to Stroke -- The Neural Pathophysiology of Stroke
We also know that the brain is remarkably tolerant of ischemia.
- Normal cerebral blood flow is in the vicinity of 60ml/100gm/minute.
- Blood flow must be reduced to less than 23ml/100gm/minute for neurons to cease functioning.
- Blood flow must be reduced below 18ml/100gm/minute before irreversible changes start to occur, and the rapidity with which these changes takes place depends on how far below 18 the blood flow is reduced.
Thus, blood flow of 17ml/100gm/minute might be tolerated for several hours.
Copyright 2000